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To start off, Misa Amane basically loses all of her previous memories about Death Note and using Death Note but she retains her memories of her time with Light and her love with Light. Well, it can be said that it is in the nature of anyone holding Death Note to suffer misfortune in his or her life and the same happens with Amane. After the Death of his beloved Light, Misa Amane felt into deep despair.
It was due to Matsuda, as he was the one who let this information get to Amane and which left her in such state. It happened when she regained her memory about Light and Rem there being Rem told Misa Amane that if in any manner she got killed than she will kill Light on her own and make him pay for his deeds.
Amane told Rem that she is not in the favor of being loved by a Shinigami but the fact is that she cannot live without Light as she deeply loves him and would even die for him. Well, Light wouldn't even try to kill Misa in any way as he knew that she is badly in love with him.
At the end we don't know what happened with Amane as it is not mentioned in the Manga as well as in the end the person who is shown wearing a black robe is actually a follower of Kira. So, no one knows what happen with Misa Amane till now.
There are also some speculations related to Misa Amane as some readers have a point that she is basically dead after she jumped off a building where she is last seen with a grim look on her face as she is soul less and she doesn't seems to have any motive to live any longer than this. So, maybe she could have just jumped off that building to put an end to her misery.
Did Light ever loved back Misa Amane?
Well, Light is the main protagonist of our series and he is the most intelligent or genius boy in the series apart from L. But he did very unethical things to bring a change in this world as he thought that he is the only one who can put an end to all the bad deeds that is happening in the world and then he will become the God of the new world. But he was just crazy thinking about this whole stuff.
His ways of doing things was always unethical and he even killed innocent people in the process. He kept Misa Amane beside him just to gain profit from her as she was the other Death Note user. He was always exceptional in conducting things. When she and Light met for the first time he knew that Amane loved her and he uses this as his plus point and kept her with him only because she was useful. This can also be clearly seen in the manga and anime.
It is sad to see that Light only see Amane as a commodity and nothing else more than and on the other hand Amane whole heartedly loved Light. Amane had Shinigami eyes which picked up Light's interest and soon they were together. It is not a lie that I say that Light and Amane looked good together. Almost everyone who read or watch Death Note series feel the same. Well, she always tried to help Light and always put him above anything else.
It was a case when Light was near in finding out about L's identity and Amane was solving that but when she was not doing good she seems desperate and wanted to be of help to Light. This only shows that Amane loved Light but it was not tye other way round.